"The difference in how your life works out, is not what happens, it's what you do." If you want to make an impact that sets you apart from everyone else, do something different. If you want to make a difference in your life, do something different from what you have been doing - make a change. It sounds cheesy but that's how it works. If all that you've been up to has not been enough, then you've got to up your act.
Environment, friends, habit, mentality, principles, ideas, lifestyle, anything and everything you know deep down has not really been contributing to get you the kind of results you want, CHANGE THEM. That's how you make a difference - opportunities do not make the difference, it's what you do with those opportunities that makes the difference.